Isopimpinellin

一种具有多种生物活性的呋喃香豆素；在无细胞测定中抑制脂质过氧化；在20µM浓度下防止RBL-2H3细胞释放组胺并激活NF-κB；在70mg/kg浓度下防止SENCAR小鼠中苯并[a]芘-DNA加合物形成；在30、70或150mg/kg浓度下减少SENCAR小鼠中由DMBA引发和促进的乳头状瘤数量。A furanocoumarin with diverse biological activities; inhibits lipid peroxidation in a cell-free assay; prevents histamine release from, and activation of NF-κB in, RBL-2H3 cells at 20 µM; prevents benzo[a]pyrene-DNA adduct formation in SENCAR mice at 70 mg/kg; reduces the number of papillomas initiated and promoted by DMBA in SENCAR mice at 30, 70, or 150 mg/kg.分子式C13H10O5分子量246.2O=C1OC2=C(C=C1)C(OC)=C3C=COC3=C2OC