8-Azaadenosine

核苷类似物和ADAR1抑制剂；在1和2µM浓度下抑制TPC-1和Cal-62甲状腺癌细胞中的RNAA到I编辑以及它们的侵袭和迁移；在2mg/kg浓度下增加HBV感染模型中从小鼠脾脏中分离的CD8+T细胞体外分泌IFN-γ和TNF-α；在同一模型中降低血清HBsAg水平。A nucleoside analog and an ADAR1 inhibitor; inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and Cal-62 thyroid cancer cells at 1 and 2 µM; increases the ex vivo secretion of IFN-γ and TNF-α from CD8+ T cells isolated from mouse spleen in a model of HBV infection at 2 mg/kg; decreases serum HBsAg levels in the same model.分子式C9H12N6O4分子量268.2O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(N)=C3N=N2