Anle138b

蛋白质聚集抑制剂；浓度为10µM时可抑制α-突触核蛋白寡聚体的形成和PrPSc朊病毒的传播；剂量为1mg/只时可抑制朊病毒感染小鼠大脑中PrPSc的积累，并提高其存活率；减少大脑中tau的沉积，挽救阿尔茨海默病人类tau转基因小鼠模型中的葡萄糖代谢衰退；在MSA小鼠模型中，以0.6和2g/kg饲料喂养可减少α-突触核蛋白寡聚体和神经胶质细胞质内含体的形成、小胶质细胞活化和多巴胺能神经元降解，并保持运动功能。An inhibitor of protein aggregation; inhibits α-synuclein oligomer formation and PrPSc prion propagation at 10 µM; inhibits brain accumulation of PrPSc in, and increases survival of, prion-infected mice at 1 mg/animal; reduces brain tau deposition and rescues glucose metabolic decline in a human tau transgenic mouse model of Alzheimer's disease; dietary administration reduces the formation of α-synuclein oligomers and glial cytoplasmic inclusions, microglial activation, and dopaminergic neuron degradation, as well as preserves motor function, in a mouse model of MSA at 0.6 and 2 g/kg chow.分子式C16H11BrN2O2分子量343.2BrC1=CC=CC(C2=CC(C3=CC=C4C(OCO4)=C3)=NN2)=C1