Escin Ia

一种具有多种生物活性的三萜皂苷；在无细胞测定中抑制HIV-1蛋白酶活性（IC50=35µM）；在2.5、5和10µM时抑制MDA-MB-231细胞的侵袭和EMT；在100和200mg/kg时降低小鼠中由乙酸引起的血管通透性增加，或在大鼠中由组胺引起的血管通透性增加；在100mg/kg时抑制口服葡萄糖大鼠中血糖水平的升高。A triterpenoid saponin with diverse biological activities; inhibits HIV-1 protease activity in a cell-free assay (IC50 = 35 µM); inhibits the invasion of, and EMT in, MDA-MB-231 cells at 2.5, 5, and 10 µM; reduces increases in vascular permeability induced by acetic acid in mice, or histamine in rats, at 100 and 200 mg/kg; inhibits increases in serum glucose levels in oral glucose-loaded rats at 100 mg/kg.分子式C55H86O24分子量1131.3OC[C@]12[C@](CC(C)([C@H]([C@@H]2OC(C)=O)OC(/C(C)=C/C)=O)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@](C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)CO)([H])CC8)C)([H])[C@]8(C)[C@@]3(C[C@H]1O)C