Gossypetin

一种具有多种生物活性的类黄酮；在20µM浓度下，可抑制MKK3和MKK6，并在KYSE-450和KYSE-510食管癌细胞中诱导细胞凋亡和细胞周期停滞于G2期；在无细胞测定中，可清除DPPH自由基并抑制铜诱导的脂质过氧化；在10mg/kg浓度下，可降低高脂饮食引起的血清胆固醇、甘油三酯和LDL胆固醇水平升高，并减少动脉粥样硬化兔模型中主动脉细胞外脂质和泡沫细胞沉积。A flavonoid with diverse biological activities; inhibits MKK3 and MKK6, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells at 20 µM; scavenges DPPH radicals and inhibits copper-induced lipid peroxidation in cell-free assays; reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis at 10 mg/kg.分子式C15H10O8分子量318.2OC(C=C(C(OC1=C(C(O)=CC(O)=C1O)C2=O)=C2O)C=C3)=C3O