Kaempferol 3-O-galactoside

一种具有多种生物活性的黄酮类化合物；能够抑制分泌型磷脂酶A₂（sPLA₂），其半数抑制浓度（IC₅₀）为17.6µM；在12.5µM、25µM和50µM浓度下，降低NCI-H460非小细胞肺癌（NSCLC）细胞中Akt蛋白水平，并诱导细胞凋亡；在细胞外实验中，以200µg/ml浓度清除DPPH自由基和超氧阴离子；在小鼠模型中，以150mg/kg剂量减少TPA诱导的耳部水肿和角叉菜胶诱导的爪部水肿。A flavonoid with diverse biological activities; inhibits sPLA2 (IC50 = 17.6 µM); decreases protein levels of Akt and induces apoptosis in NCI H460 NSCLC cells at 12.5, 25, and 50 µM; scavenges DPPH radicals and superoxide anions in cell-free assays at 200 µg/ml; reduces TPA-induced ear edema and carrageenan-induced paw edema in mice at 150 mg/kg.分子式C21H20O11分子量448.4O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(C=C3)O)=C1O[C@@H]4O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)CO