IC87201

nNOS-PSD-95蛋白质-蛋白质相互作用的抑制剂；抑制PSD-95与nNOS的结合(IC50=31µM)；抑制NMDA诱导的原代大鼠海马神经元cGMP生成(IC50=2.7µM)；在10µM浓度下减少MPP+诱导的原代大鼠皮质神经元ROS生成、细胞色素c释放和细胞凋亡；降低小鼠的热痛觉过敏(ED50=0.1mg/kg)，以及CCI诱发的神经性疼痛大鼠模型中的机械性异常性疼痛；在1mg/kg浓度下减少小鼠在强迫游泳和悬尾测试中的静止时间。An inhibitor of the nNOS-PSD-95 protein-protein interaction; inhibits the binding of PSD-95 to nNOS (IC50 = 31 µM); inhibits NMDA-induced cGMP production in primary rat hippocampal neurons (IC50 = 2.7 µM); reduces MPP+-induced production of ROS, cytochrome c release, and apoptosis in primary rat cortical neurons at 10 µM; decreases thermal hyperalgesia in mice (ED50 = 0.1 mg/kg), as well as mechanical allodynia in a rat model of CCI-induced neuropathic pain; reduces immobility time in the forced swim and tail suspension tests in mice at 1 mg/kg.分子式C13H10Cl2N4O分子量309.2ClC1=CC(CNC2=CC3=C(N=NN3)C=C2)=C(O)C(Cl)=C1