Benzyl-2-acetamido-2-deoxy-α-D

粘蛋白合成抑制剂；浓度为2mM时可抑制Caco-2、HT-29和T84结肠癌细胞中的葡萄糖胺标记；浓度为0.4、0.6和0.8mg/ml时可增强Capan-1和HPAF-II细胞中5-氟尿嘧啶诱导的细胞死亡；与对照LS174T细胞相比，在苄基-α-GalNAc存在下生长的LS174T结肠癌细胞在小鼠异种移植模型中表现出肝转移减少。An inhibitor of mucin synthesis; inhibits glucosamine labeling in Caco-2, HT-29, and T84 colon cancer cells at 2 mM; enhances 5-fluorouracil-induced cell death in Capan-1 and HPAF-II cells at 0.4, 0.6, and 0.8 mg/ml; LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.分子式C15H21NO6分子量311.3CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@H]1OCC2=CC=CC=C2)=O