Prulifloxacin

乌利沙星的前体药物；提高小鼠在各种全身细菌感染模型中的存活率（ED50s=0.35-23mg/kg）；提高小鼠在肺炎克雷伯菌诱发的呼吸道感染模型中的存活率（ED50=0.981mg/kg）。A prodrug from of ulifloxacin; increases survival in various mouse models of systemic bacterial infection (ED50s = 0.35-23 mg/kg); increases survival in a mouse model of K. pneumoniae-induced respiratory tract infection (ED50 = 0.981 mg/kg).分子式C21H20FN3O6S分子量461.5FC1=C(C=C2C(C(C(C(O)=O)=C3SC(C)N32)=O)=C1)N(CC4)CCN4CC(O5)=C(C)OC5=O