BMS 1166

PD-1和PDL1之间蛋白质-蛋白质相互作用的抑制剂（HTRF测定中IC50=1.4nM）；在共培养中增加表达PD-1的Jurkat细胞与表达PD-L1的CHO细胞的活化（报告测定中的EC50=276nM）。An inhibitor of the protein-protein interaction between PD-1 and PDL1 (IC50 = 1.4 nM in a HTRF assay); increases the activation of Jurkat cells expressing PD-1 in co-culture with CHO cells expressing PD-L1 (EC50 = 276 nM in a reporter assay).分子式C36H33ClN2O7分子量641.1N#CC1=CC=CC(COC(C=C(C(Cl)=C2)OCC3=C(C(C4=CC=C(OCCO5)C5=C4)=CC=C3)C)=C2CN6[C@@H](C(O)=O)C[C@H](C6)O)=C1