Cyclo(L-His-L-Pro)

一种环状神经肽和TRH代谢物；在中枢神经系统中普遍表达，但也存在于胃肠道和血液中；减少LPS诱导的ROS和NO生成，以及BV-2小胶质细胞中NF-κB的易位；连续饮用乙醇六周后，大鼠脑中的水平会升高；以1µmol/kg的浓度减少大鼠因乙醇引起的睡眠时间；在热板试验中诱导镇痛，并减少小鼠因乙酸引起的翻滚。A cyclic neuropeptide and metabolite of TRH; ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood; reduces LPS-induced production of ROS and NO, as well as translocation of NF-κB in BV-2 microglia; levels are increased in rat brain after six weeks of continuous ethanol consumption; reduces ethanol-induced sleep time in rats at 1 µmol/kg; induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice.分子式C11H14N4O2分子量234.3O=C(N1[C@@]2([H])CCC1)[C@H](CC3=CN=CN3)NC2=O