IMS 2186

抗脉络膜新生血管剂；抑制NIH3T3小鼠和IMR-90人成纤维细胞(IC50s=0.5-3µM)的增殖，以及抑制8种人类癌细胞系(IC50s=0.3-3µM)的增殖；在伤口愈合和腔内试验中，10µM可降低THP-1巨噬细胞的迁移；在MatrigelTM栓塞试验中，20µg/只动物可抑制VEGF诱导的小鼠血管形成；在激光诱导的脉络膜新生血管大鼠模型中，100µg/只眼可减少眼部渗漏以及细胞增殖和浸润。An anti-choroidal neovascularization agent; inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines (IC50s = 0.3-3 µM); decreases migration of THP-1 macrophages in wound healing and chamber assays at 10 µM; inhibits VEGF-induced blood vessel formation in a MatrigelTM plug assay in mice at 20 µg/animal; reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization at 100 µg/eye.分子式C18H16O4分子量296.3CC1=CC=C(OC/C(C2=O)=C\C3=CC=C(OC)C(O)=C3)C2=C1