N106

SERCA2ASUMO化激活剂；激活SUMO活化酶E1，从而增加成年大鼠分离心肌细胞中SUMO化和SERCA2A活性，浓度为0.1-1µM；增加相同细胞的收缩力；在10mg/kg剂量下增加压力超负荷诱发心力衰竭小鼠模型中的心脏SERCA2ASUMO化和收缩力。An activator of SERCA2A SUMOylation; activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes from 0.1-1 µM; increases contractility in the same cells; increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure at 10 mg/kg.分子式C17H14N4O3S分子量354.4COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1