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- 2025年07月20日
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文献和实验Synthesis of Cbz-Protected Ketomethylene Dipeptide Isosteres
Ketomethylene peptide isosteres have been the focus of a variety of synthetic studies because of their potential as therapeutic agents in the treatment of medical conditions mediated by proteases ( 1 – 3 ). The dipeptide core units
Syntheses of Norstatine, Its Analogs, and Dipeptide Isosteres by Means of -Lactam Synthon Method
with the design and synthesis of various enzyme inhibitors. Indeed, statine, norstatine, and their analogs, as well as a variety of dipeptide isosteres, have been developed and incorporated in various inhibitors of enzymes such as renin and HIV-1 protease
Preparation of the Syntex Adjuvant Formulation (SAF, SAF-m, and SAF-1)
The Syntex adjuvant formulation (SAF) is an effective adjuvant composed of a muramyl dipeptide derivative (threonyl-MDP) in an oil-in-water (o/w) emulsion vehicle. Threonyl-MDP (N-acetyl muramyl-L-threonyl-D-isoglutamine) was identified
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