Hexarelin

GHS-R的肽激动剂；选择性地与CD36上的GHS-R结合（IC50s分别为15.9和2,080nM）；以300µg/kg的剂量增加新生大鼠的血浆生长激素水平；以每天0.3mg/kg的剂量改善左心室功能并减少暂时性LAD结扎诱发的心肌缺血小鼠模型中的纤维化。A peptide agonist of GHS-R; selectively binds to GHS-R over CD36 (IC50s = 15.9 and 2,080 nM, respectively); increases plasma growth hormone levels in neonatal rats at 300 µg/kg; improves left ventricular function and reduces fibrosis in a transient LAD ligation-induced mouse model of myocardial ischemia at 0.3 mg/kg per day.分子式C47H58N12O6分子量887O=C(N[C@H](CC1=C(C)NC2=C1C=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)[C@@H](N)CC6=CN=CN6