Aurintricarboxylic Acid (ammon

一种蛋白质合成抑制剂；能够抑制多种酶的活性，包括DNase I、RNase A、S1以及胰蛋白酶和胰凝乳蛋白酶，且呈浓度依赖性；在Vero细胞中抑制SARS-CoV的复制（EC50=200µg/ml）和EV71的复制（EC50=2.9µM），同时减少HIV-1和HIV-2在MT-4细胞中诱导的细胞病变效应（IC50分别为1.1µg/ml和0.85µg/ml）；在100µM浓度下抑制血根碱诱导的K562白血病细胞凋亡；在20mg/kg剂量下减少中枢神经系统CD4+ T细胞的浸润，并减轻小鼠髓鞘少突胶质糖蛋白诱导的实验性自身免疫性脑脊髓炎（EAE）模型中的后肢无力和瘫痪。An inhibitor of protein synthesis; inhibits the activity of a variety of enzymes, including DNase I, RNase A, and S1, as well as trypsin and chymotrypsin in a concentration-dependent manner; inhibits replication of SARS-CoV (EC50 = 200 µg/ml) and EV71 in Vero cells (EC50 = 2.9 µM), as well as reduces cytopathogenicity induced by HIV-1 and HIV-2 in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively); inhibits sanguinarine-induced apoptosis in K562 leukemia cells at 100 µM; decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced EAE at 20 mg/kg.分子式C22H11O9 • 3NH4分子量473.4[O-]C(C(C(C=C/1)=O)=CC1=C(C2=CC=C(O)C(C([O-])=O)=C2)\C3=CC=C(O)C(C([O-])=O)=C3)=O.[NH4+].[NH4+].[NH4+]