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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Glyphosate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
1071-83-6
- 规格：
50mg
| 基本信息 | |
| CAS | No.1071-83-6 |
| 中文名称 | 草甘膦 |
| 英文名称 | Glyphosate |
| 别名 | 草甘膦;N-(膦酰基甲基)甘氨酸;N-膦羧基甲基甘氨酸;N-(磷酰基甲基)甘氨酸;N-(膦酰甲基)氨基乙酸 |
| 分子式 | C3H8NO5P |
| 分子量 | 169.07 |
| 溶解性 | Soluble in Water |
| 纯度 | ≥95% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 213-997-4 |
| MDL | MFCD00055350 |
| SMILES | C(C(=O)O)NCP(=O)(O)O |
| InChIKey | XDDAORKBJWWYJS-UHFFFAOYSA-N |
| InChI | InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9) |
| PubChem CID | 3496 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是一种氨基酸甘氨酸的除草衍生物。 |
| 生物活性 | Glyphosate targets and blocks a plant metabolic pathway not found in Animals， the shikimate pathway， required for the synthesis of aromatic Amino acids in Plants.Glyphosate is a high-efficiency， low-toxicity， broad-spectrum herbicide. [1-2] |
| In Vitro | Glyphosate exposure could interfere with mouse oocyte maturation by generating oxidative stress and early Apoptosis.[2] |
| 细胞实验 | Mouse oocytes had reduced rates of germinal vesicle breakdown (GVBD) and first polar body extrusion (PBE) after treatment with 500 μM glyphosate. Reactive Oxygen Species (ROS) were found in mouse oocytes exposed to glyphosate， as shown by changes in the mRNA expression of related antioxidant enzyme genes (cat， sod2， gpx). After 14 h of exposure to glyphosate， metaphase II (MII) mouse oocytes displayed an abnormal spindle morphology and DNA double-strand breaks (DNA-DSBs). Simultaneously， mitochondria showed an aggregated distribution and decreased membrane potential in mouse oocytes exposed to glyphosate.[2] |
| 数据来源文献 | [1]. Greim H， et al. Evaluation of carcinogenic potential of the herbicide glyphosate， drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45(3):185-208. [2]. Zhang JW， et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435. |
| 单位 | 瓶 |
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文献和实验|998894|gb|S78179.1|S78179 Oryctolagus cuniculus type XII... 32 0.037 gi|31072033|gb|AC122153.4| Oryctolagus cuniculus clone LB1-... 28 0.58 gi|1496|emb|X52496.1|OCCAATP Rabbit mRNA for calcium ATPase 28 0.58 gi|1468|emb|X02814.1|OCATPDR Rabbit mRNA
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