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- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Capsazepine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
138977-28-3
- 规格：
100mg/50mg/10mM*1mL in DMSO/5mg/10mg
| 规格： | 100mg | 产品价格： | ￥5790.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥3190.0 |
| 规格： | 10mM*1mL in DMSO | 产品价格： | ￥770.0 |
| 规格： | 5mg | 产品价格： | ￥483.0 |
| 规格： | 10mg | 产品价格： | ￥780.0 |
是TRPV1 受体拮抗剂。
| 基本信息 | |
| CAS | No.138977-28-3 |
| 中文名称 | 辣椒平 |
| 英文名称 | Capsazepine |
| 别名 | 辣椒平;Capsazepine; |
| 分子式 | C19H21ClN2O2S |
| 分子量 | 376.9 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00153778 |
| SMILES | S=C(N1CCCC2=CC(O)=C(O)C=C2C1)NCCC3=CC=C(Cl)C=C3 |
| 靶点 | TRPV1 |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | Capsazepine是TRPV1 受体拮抗剂。 |
| 生物活性 | Capsazepine是TRPV1的拮抗剂，IC50 为562 nM。[1-4] |
| IC50 | TRPV1：562nM[1] |
| In Vitro | Capsazepine(50 μM)optimally enhances the upregulation of(death receptors)DRs without affecting cell viability HCT116 cells. Capsazepine(30-50 μM)induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells[1]. Capsazepine(1-100 μM，45 min preincubation)inhibits the evoked CGRP-LI release. Capsazepine(3-100 μM)prevents low pH- and capsaicin-induced CGRP-LI release from rat soleus muscle at concentrations which do not affect the release evoked by KCl. Capsazepine(3-100 μM，without 10 μM)produces a nonspecific inhibitory effect on CGRP-LI release from peripheral endings of the capsaicin-sensitive primary afferent neurone[2]. |
| 细胞实验 | Capsazepine(15 mg/kg，s.c.)prevents the increase in respiratory system resistance and decreases the increase in tissue damping during endotoxemia. Capsazepine attenuates lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS[3]. |
| 细胞实验 | To verify the role of TRPV1 on lung mechanics during LPS-induced ALI，the animals(n = 10 per group)are pre-treated with vehicle or Capsazepine(15 mg/kg; s.c.)，then receive saline or LPS(5 mg/kg，i.p.)after 10 min. Thus，the mice are randomly divided into four groups with 10 mice in each group:(i)control(vehicle + saline)，(ii)Capsazepine + saline，(iii)vehicle + LPS and(iv)Capsazepine + LPS. After a 24-hr treatment with saline or LPS，the mice are anaesthetized and paralysed and lung mechanics function is evaluated. Afterwards，the lungs are removed for histology.[3] |
| 动物实验 | To assay intracellular ROS，HCT116 cells are preincubated with 20 μM dichlorofluorescein diacetate(DCF DA)for 15 min at 37°C and then treated with Capsazepine. After 1 h of incubation，the increase in fluorescence resulting from the oxidation of DCF DA to DCF is measured by flow cytometry. The mean fluorescence intensity at 530 nm is calculated for at least 10，000 cells at a flow rate of 250-300 cells/s.[1] |
| 数据来源文献 | [1]. Sung B， et al. Capsazepine， a TRPV1 antagonist， sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic Biol Med. 2012 Nov 15;53(10):1977-87. [2]. Santicioli P， et al. Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH， capsaicin and potassium in rat soleus muscle. Br J Pharmacol. 1993 Oct;110(2):609-12. [3]. Cabral LD， et al. The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia. Basic Clin Pharmacol Toxicol. 2016 Nov;119(5):421-427. [4]. Wang J， et al. Anti-inflammatory and retinal protective effects of capsaicin on ischaemia-induced injuries through the release of endogenous somatostatin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814. |
| 单位 | 瓶 |
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IC2340 辣椒平 跨膜转运/离子通道 索莱宝
￥483 - 5790
