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- IB1440
- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
BEC Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
222638-67-7
- 规格：
50mg/25mg/10mg/1mg/5mg
| 规格： | 50mg | 产品价格： | ￥4220.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥2880.0 |
| 规格： | 10mg | 产品价格： | ￥1394.0 |
| 规格： | 1mg | 产品价格： | ￥350.0 |
| 规格： | 5mg | 产品价格： | ￥810.0 |
| 基本信息 | |
| CAS | No.222638-67-7 |
| 英文名称 | BEC Hydrochloride |
| 别名 | ;BECHCl;S-(2-boronoethyl)-L-cysteine.;Aricept，E-2020DonepezilHCl; |
| 分子式 | C5H12BNO4S·HCl |
| 分子量 | 229.48 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03453539 |
| SMILES | B(CCSC[C@@H](C(=O)O)N)(O)O.Cl |
| 靶点 | Arginase |
| 通路 | Metabolic Enzyme&Protease |
| 背景说明 | BEC Hydrochloride是一个竞争性的 Arginase II抑制剂。 |
| 生物活性 | BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[1]. |
| IC50 | Ki: 0.31μM(BEC hydrochloride，at pH 7.5) and 30nM(BEC hydrochloride，at pH 9.5)[1] |
| In Vitro | The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster，thereby mimicking the tetrahedral intermediate(and its flanking transition states)in the arginine hydrolysis reaction[2]. |
| 细胞实验 | Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis，which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation，mucus metaplasia，NF-κB DNA binding，and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC，and leads to further increases in airways hyperresponsiveness[3]. |
| 数据来源文献 | [1]. Colleluori DM， et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. [2]. Kim NN， et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. [3]. Ckless K， et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease， in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15;181(6):4255-64. |
| 单位 | 瓶 |
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IB1440 BEC Hydrochloride 免疫学/炎症 索莱宝
￥350 - 4220
