- ￥120
- Solarbio
- 北京
- IB1320
- 2025年07月23日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
2-Benzoxazolinone
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
59-49-4
- 规格：
100mg
| 基本信息 | |
| CAS | No.59-49-4 |
| 中文名称 | 2-苯并唑啉酮 |
| 英文名称 | 2-Benzoxazolinone |
| 别名 | 2-Hydroxybenzoxazole;1，3-Benzoxazol-2(3H)-one |
| 分子式 | C7H5NO2 |
| 分子量 | 135.12 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Light brown to brown Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-430-0 |
| MDL | MFCD00005716 |
| SMILES | C1=CC=C2C(=C1)NC(=O)O2 |
| InChIKey | ASSKVPFEZFQQNQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9) |
| PubChem CID | 6043 |
| 靶点 | Parasite |
| 通路 | Anti-infection |
| 背景说明 | 是一种抗利什曼原虫试剂。 |
| 生物活性 | 2-Benzoxazolinone (BOA), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate.[1] 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[2] |
| IC50 | LC50: 40μg/mL(L. donovani)[2] |
| In Vitro | BOA induces oxidative stress in mung bean as indicated by increased generation of H2O2，enhanced LP and accumulation of endogenous PRO. It is accompanied by an upregulation of the activities of various scavenging enzymes—SODs，peroxidases，CATs and GR—in roots and leaves of mung bean in response to BOA exposure.[1] The LC50 values for BOA and pentamidine are 40 pg/ml and 39.8 pg/mi，respectively. BOA showed antileishmanial activity and compares well with pentamidine. [2] |
| 细胞实验 | Promastigote para- sites in the stationary phase of growth(1 x io parasite/mi)were inoculated into culture tubes containing BHI-agar as solid part and HBSS as hquid part. To these tubes different concentrations(10 to 100 pg/mi，DMSO/PBS)of BOA and pentamidine were added，respectively. The inhibitory effect of BOA was compared with pentamidine which is known to be active against leishmaniasis，and with untreated control cultures. The whole operation was carried out aseptically in an ultraviolet chamber and the tubes were incubated for 5 days at 22 °C. The toxicity of DMSO was determined by adding different amounts of solvent(0.1 to 1.5%)to suspensions of promastigotes under the conditions described above. After five days the value of the non-toxic dilution was found to be 0.6% and growth inhibition(up to 15%)was observed between 0.6% and 1 %; therefore，higher concentrations of DMSO were never used. Antileishmanial activity of each of the com_x0002_pounds was determined by counting the number of live parasites per field microscopically. The LC55 values were calculated by probit analysis and no mortallty was observed in mice when BOA was administered((p.)in the doses ranging from 0.25—1 g/kg. The mice were kept under observation for one week.[2] |
| 激酶实验 | For the BOA treatment，we followed the method used by Burgos and Talbert，wherein seeds germinated on a filter paper disc moistened with BOA and grow until the measurement of seedling length. Seeds of mung bean were surface sterilized with sodium hypochlorite(0.1%，w/v)followed by washing with distilled water three times. These were subjected to germination in 15 cm diameter Petri dishes lined with a Whatman no. 1 filter circle and moistened with 7 ml of respective BOA treatment solution or distilled water(control). The 7 ml of the 0.1，0.5，1.0，2.5，and 5.0 mM BOA solution used cor_x0002_respond to nearly 0.0946，0.473，0.946，2.365，4.73 mg ml–1 BOA，respectively. It was in the range similar to that used by Burgos and Talbert [13]. Twenty-five mung bean seeds were used in each Petri dish. Five replicates were maintained for each treatment in a completely randomized manner. All the Petri dishes were placed in a seed germinator maintained at 25 ± 2 °C，75 ± 3% relative humidity and a 16 h:8 h light: dark photoperiod with a photosynthetic photon flux density of 150 μmol m–2 s–1. After 7 days，root and shoot length of emerged seedlings from each treatment were measured. Further，roots and leaves from each treatment were harvested and stored at –80 °C prior to enzyme extraction and other estimations.[1] |
| 数据来源文献 | [1] Batish D R ， Singh H P ， Setia N ， et al. 2-Benzoxazolinone (BOA) induced oxidative stress， lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus).[J]. Plant Physiol Biochem， 2006， 44(11-12):819-827. [2]. Kapil A， et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验
技术资料暂无技术资料 索取技术资料
IB1320 2-苯并唑啉酮 抗感染 索莱宝
￥120
