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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Amitraz
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
33089-61-1
- 规格：
250mg/100mg
| 规格： | 250mg | 产品价格： | ￥340.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥200.0 |
| 基本信息 | |
| CAS | No.33089-61-1 |
| 中文名称 | 双甲脒 |
| 英文名称 | Amitraz |
| 别名 | NSC 324552;BTS-27419 |
| 分子式 | C19H23N3 |
| 分子量 | 293.41 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 251-375-4 |
| MDL | MFCD00069396 |
| SMILES | CN(/C=N/C1=CC=C(C)C=C1C)/C=N/C2=CC=C(C)C=C2C |
| InChIKey | QXAITBQSYVNQDR-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H23N3/c1-14-6-8-18(16(3)10-14)20-12-22(5)13-21-19-9-7-15(2)11-17(19)4/h6-13H,1-5H3 |
| PubChem CID | 36324 |
| 靶点 | Adrenergic Receptor |
| 通路 | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| 背景说明 | Amitraz具有α-ADr能激动剂活性。 |
| 生物活性 | Amitraz (NSC 324552) 是一种α2 ADr能受体激动剂。它是非系统性杀螨剂和杀虫剂。[1-2] |
| In Vitro | Amitraz was not cytotoxic to human luteinized granulosa cells at concentrations of 1，10 or 50 μg/ml for exposures of 2-72 h While the highest concentration of amitraz tested，100 μg/ml，caused significant cell death after exposures of 24，48 and 72 h. Amitraz decreased the amount of progesterone produced by each cell after a 4 h exposure; the reduction in progesterone concentration was not caused by decreased cell viability[1]. |
| 细胞实验 | Amitraz is an α2-adrenergic receptor(α2-AR)agonist that adversely affects the mammalian reproductive system by binding to presynaptic α2-AR in the hypothalamus，thus inhibiting noradrenalin release and decreasing GnRH secretion. When 30 mg/kg of amitraz was administered to rats，the ovulatory LH surge was prevented. Amitraz inhibited insulin but stimulated glucagon secretion in a perfused rat pancreas model. Amitraz also decreased intestinal motility，and inhibited prostaglandin synthesis by bovine seminal vesicle microsomes. Amitraz can be absorbed through the skin and can exert systemic effects via the vascular system in humans[1]. Low doses of AMZ(l-25 mg/kg)decreased motor activity and altered the rates and patterns of responding under schedule-controlled conditions. Intermediate doses(50-100 mg/kg)affect visual-evoked potentials and lower body weight and temperature. In addition，100 mg/kg produces slight MAO inhibition and characteristic signs of intoxication(e.g.，weight loss and hyperreactivity). High doses(>lOO mg/kg)produce more pronounced MAO inhibition，extreme weight loss and hyperreactivity，aggression，and lethality[2]. |
| 数据来源文献 | [1] Young FM， et al. Hum Reprod. 2005， 20(11):3018-25. [2] Moser VC， et al. Fundam Appl Toxicol. 1989， 12(1):12-22. |
| 单位 | 瓶 |
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文献和实验2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
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