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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Magainin II
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
108433-95-0
- 规格：
5mg/1mg
| 规格： | 5mg | 产品价格： | ￥3390.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥1590.0 |
是在非洲爪蟾皮肤中发现的一种抗菌肽。可以诱导细菌细胞死亡，表现出凋亡特性。
| 基本信息 | |
| CAS | No.108433-95-0 |
| 英文名称 | Magainin II |
| 别名 | 蛙皮素2;Magainin2;magainin2peptide，Xenopus;Z-12Peptide; |
| 分子式 | C114H180N30O29S |
| 分子量 | 2466.9 |
| 溶解性 | Soluble in Water |
| 纯度 | ≥97% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00133522 |
| SMILES | CCC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC3=CC=CC=C3)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)O)NC(=O)CN |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Magainin II是在非洲爪蟾皮肤中发现的一种抗菌肽。可以诱导细菌细胞死亡,表现出凋亡特性。 |
| In Vitro | Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein[1]. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum，a protozoan，in pond water caused an osmotic swelling of the cell and a subsequent cell burst，suggesting that the peptide could perturb membrane functions responsible for osmotic balance[2]. |
| 细胞实验 | Escherichia coli cells are incubated with magainin 2(50 μg /mL). The cultures are acquired after incubation for 0，2，4，6，and 8 h，respectively，and spread onto LB agar plates，and then the colony-forming units are counted after incubation for 24 h at 37°C. The percentage survival is determined relative to the control treatment[1]. |
| 数据来源文献 | [1]. M Zasloff， et al. Magainins， a class of antimicrobial peptides from Xenopus skin: isolation， characterization of two active forms， and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. [2]. K Matsuzaki， et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400. |
| 单位 | 瓶 |
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