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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Troglitazone
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
97322-87-7
- 规格：
100mg/50mg/10mg/5mg
| 规格： | 100mg | 产品价格： | ￥4904.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥2778.0 |
| 规格： | 10mg | 产品价格： | ￥780.0 |
| 规格： | 5mg | 产品价格： | ￥483.0 |
一种新型的有效PPARγ激动剂，具有抗炎和抗肿瘤活性。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Structural elucidation and antidiabetic activity of fucosylated chondroitin sulfate from sea cucumber Stichopus japonicas
成员:Pi-Xian Gong, Qin-Ying Li, Yan-Chao Wu, Wen-Yu Lu, Jun Zeng, Hui-Jing Li
论文因子:9.381 发表期刊:CARBOHYDRATE POLYMERS pmid:33838834
| 基本信息 | |
| CAS | No.97322-87-7 |
| 中文名称 | 曲格列酮 |
| 英文名称 | Troglitazone |
| 别名 | Rezulin;Romglizone;Prelay;CS-045;Romozin;Noscal |
| 分子式 | C24H27NO5S |
| 分子量 | 441.54 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00878416 |
| SMILES | O=C(SC1CC(C=C2)=CC=C2OCC3(C)OC(C(CC3)=C4C)=C(C)C(C)=C4O)NC1=O |
| InChIKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28) |
| PubChem CID | 5591 |
| 靶点 | PPAR |
| 通路 | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| 背景说明 | 一种新型的有效PPARγ激动剂,具有抗炎和抗肿瘤活性。 |
| In Vitro | Troglitazone(2-200 μM)is cytotoxic to the pancreatic cancer cell lines(MIA Paca2 and PANC-1 cells)，with IC50s of 49.9 ± 1.2 and 51.3 ± 5.3 μM，respectively. Troglitazone(50 μM)increases chromatin condensation in MIA Paca2 and PANC-1 cells，enhances the activity of caspase-3 and decreases Bcl-2 expression[2]. Troglitazone(0，1，2，and 4 μM)sensitizes TRAIL-mediated apoptosis in human lung adenocarcinoma cells. Troglitazone enhancement of TRAIL-induced apoptosis is blocked by inhibition of autophagy，via activation of autophagy flux. In addition，the effects of troglitazone are induced by PPARγ activation in A549 cells[3]. |
| 细胞实验 | Troglitazone(200 mg/kg，p.o.)shows inhibitory effects on the growth of tumor in the MIA Paca2 xenograft model[2]. |
| 细胞实验 | Briefly，cells are seeded into 96-well plates at a density of 1 × 105 cells/well and incubated for 24 h. The cells are treated with Troglitazone in the presence or absence of other chemicals for a further 24 h using FBS-free medium. The assay utilizes the conversion of alamar blue reagent to fluorescent resorufin by metabolically active cells. The resorufin signal is measured at an excitation wavelength of 530 nm and an emission wavelength of 580 nm. The 50% growth inhibitory concentrations(IC50)are calculated according to the sigmoid inhibitory effect model E = IC50 γ/(IC50 γ + Cγ)，where E represents the surviving fraction(% of control)，C represents the drug concentration in the medium，and γ represents the Hill coefficient. For co-exposure studies，the Troglitazone dosage is set to approximately the IC50 value for each cell line[2]. |
| 动物实验 | Balb/c male mice(4 weeks old)are subcutaneously inoculated in the back with MIA Paca2 cells(5 × 106 cells/100 μL in PBS)14 days prior to starting Troglitazone administration. Mice are then orally administered 200 mg/kg Troglitazone in 0.5% methylcellulose solution or vehicle daily for 5 weeks. Tumor size is measured bi-dimensionally and the volume is calculated using the formula(length × width2) × 0.5. Body weights of mice are also monitored throughout the experiment[2]. |
| 数据来源文献 | [1]. Willson TM， et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [2]. Fujita M， et al. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017 Jul 3;36(1):91. [3]. Nazim UM， et al. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017 Apr 18;8(16):26819-26831. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Structural elucidation and antidiabetic activity of fucosylated chondroitin sulfate from sea cucumber Stichopus japonicas
成员:Pi-Xian Gong, Qin-Ying Li, Yan-Chao Wu, Wen-Yu Lu, Jun Zeng, Hui-Jing Li
论文因子:9.381 发表期刊:CARBOHYDRATE POLYMERS pmid:33838834
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