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- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，6 months.
- 保质期：
Store at -20℃，6 months.
- 英文名：
Betulinic Acid(10mM in DMSO，Sterile)
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
472-15-1
- 规格：
1ml
| CAS | 472-15-1 |
| 中文名称 | 白桦脂酸(10mM in DMSO，无菌） |
| 英文名称 | Betulinic Acid(10mM in DMSO，Sterile) |
| 分子式 | C30H48O3 |
| 分子量 | 456.7 |
| 规格 | 1ml |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Store at -20℃，6 months. |
| 运输条件 | 冷冻运输 |
| EC | 207-448-8 |
| MDL | MFCD00009619 |
| SMILES | CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O |
| InChIKey | QGJZLNKBHJESQX-UHFFFAOYSA-N |
| InChI | InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3，4)21(27)11-14-29(22，28)7/h19-24，31H，1，8-17H2，2-7H3，(H，32，33) |
| PubChem CID | 2371 |
| 靶点 | Topoisomerase |
| 通路 | DNA Damage/DNA Repair |
| 背景说明 | Betulinic acid 是一种真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂。 |
| 生物活性 | Betulinic acid is a natural pentacyclic triterpenoid， acts as a eukaryotic topoisomerase I inhibitor， with an IC50 of 5 μM， and possesses anti-HIV， anti-malarial， anti-inflammatory and anti-tumor properties.[1-5] |
| In Vitro | Betulinic acid is a eukaryotic topoisomerase I inhibitor， with an IC50 of 5 μM， and prevents topoisomerase I-DNA interaction[1]. Betulinic acid (10， 20， 40， 80， and 160 μM) significantly suppresses MDA-MB-231 cell viability in a time- and dose-dependent manner after treatment for 24 or 48 h.? Betulinic acid (20， 40 μM) causes decrease in Bcl-2 expression of MDA-MB-231 cells. Betulinic acid also induces morphological changes of MDA-MB-231 cells at 20 μM， and leads to ultrastructure changes of MDA-MB-231 cells at 40 μM[2]. Betulinic acid shows anti-HIV activities， with an EC50 of 1.4 μM in acutely infected H9 lymphocytes[4]. |
| In Vivo | Betulinic acid (10 and 30 mg/kg， p.o.) significantly abrogates colon shortening， and reduces malondialdehyde (MDA) and lipid hydroperoxide levels in dextran sulfate sodium (DSS)-induced colitis in mice. Betulinic acid (30 mg/kg， p.o.) restores superoxide dismutase (SOD)， catalase activity and glutathione (GSH) content to control levels in DSS-induced colitis in mice. Betulinic acid (30 mg/kg， p.o.) also inhibits the DSS-induced increase in inflammatory markers. Betulinic acid (3， 10， 30 mg/kg， p.o.) suppresses acetic acid-induced writhing responses and mustard oil (MO)-induced visceral nociception in mice[3]. |
| 细胞实验 | CCK-8 is used in the assay. MDA-MB-231 cells are cultured in 96-well plates at a density of 2 × 103 cells/well and then treated with DMSO vehicle or various concentrations of Betulinic acid ranging from 5 μM to 160 μM in 100 μL of medium for the indicated times. After the treatment period， the medium in each well is replaced with 110 μL of medium containing 10 μL of the CCK-8 mixture， and the plates are incubated for 1 h and 30 min at 37°C. The absorbance at a wavelength of 450 nm is measured with a microplate reader[2]. |
| 动物实验 | Female Swiss albino mice are administered vehicle (5% v/v DMSO in peanut oil) or Betulinic acid (3， 10 or 30 mg/kg) in vehicle， orally. After 1 h， acetic acid (300 mg/kg) is administered by intraperitoneal route and number of writhing response of each animal is counted for 20 min by an observer who is blind to the treatments. Writhing response is when animal rubs its abdomen on surface of table/floor with elongation of the body and extension of the hind limbs[3]. |
| 数据来源文献 | [1]. Chowdhury AR， et al. Betulinic acid， a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step， the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65. [2]. Gao Y， et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. [3]. Kalra J， et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26. [4]. Hashimoto F， et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43. [5]. Kasperczyk H， et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56. |
| 单位 | 瓶 |
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文献和实验相关实验
商品化试剂和培养基均经过严格的质量控制以保证其无菌，但它们在操作过程中可能被污染。请遵循以下指导原则进行无菌操作，避免污染。请始终使用适当的灭菌方法（如高压灭菌器、除菌过滤器）对实验室中配制的任何试剂、培养基或溶液进行灭菌。 无菌操作 请始终用 70% 乙醇擦拭双手和工作区。 将容器、培养瓶、培养板和培养皿放入细胞培养通风橱之前，先用 70% 乙醇擦拭其外部。 不要直接从试剂瓶或培养瓶中倾倒培养基和试剂。 使用无菌玻璃或一次性塑料移液管和移液器操作液体时，每只移液管只能使用一次，以避免
培养基经高压灭菌后，用经过灭菌的工具（如接种针和吸管等）在无菌条件下接种含菌材料（如样品、菌苔或菌悬液等）于培养基上，这个过程叫做无菌接种操作。在实验室检验中的各种接种必须是无菌操作。 实验台面不论是什么材料，一律要求光滑、水平。光滑是便于用消毒剂擦洗；水平是倒琼脂培养基时利于培养皿内平板的厚度保持一致。在实验台上方，空气流动应缓慢，杂菌应尽量减少，其周围杂菌也应越少越好。为此，必须清扫室内，关闭实验室的门窗，并用消毒剂进行空气消毒处理，尽可能地减少杂菌的数量
工业级-DMSO用途： 主要用于无水有机化学合成反应和医药及中间体合成反应溶剂，使用该溶剂能提高化学反应速度，提高反应物的了收率，缩短反应时间，使合成反应变得更加顺利。 试剂级-DMSO用途: DMSO用作液体层析溶剂，同时用作测试物质紫外消光值上时用作参照物，存在于液体形态。 (责任编辑：大汉昆仑王)
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白桦脂酸(10mM in DMSO，无菌)
¥580
