- ￥1295
- Sigma-Aldrich
- 进口
- P4338-500G
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Poly(ethylene glycol)
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
25322-68-3
- 规格：
500G
属性
产品名称
聚（乙二醇）, BioXtra, average mol wt 3,350, powder
产品线
BioXtra
质量水平
200
表单
powder
分子量
average mol wt 3,350
杂质
≤0.01% Phosphorus (P)
≤0.1% Insoluble matter
溶解性
water: soluble (PEG is soluble in water approximately 670 mg/ml, 20 °C)
密度
1.0962 g/mL at 60 °C
1.0764 g/mL at 80 °C
痕量阴离子
chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
痕量阳离子
Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%
Ω端
hydroxyl
α端
hydroxyl
SMILES字符串
C(CO)O
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
一般描述
应用
聚乙二醇可用作药物最终剂型的外部包衣，为原料药提供防潮保护。例如，drop printing（液滴打印）技术可使聚乙二醇包覆在萘普生固体分散体上。PEG包衣可保护固体分散体，避免潮湿导致的结晶加快，并增强稳定性。
以聚乙二醇作为有机改性剂，通过溶胶-凝胶技术可制备纳米结构的羟磷灰石(HAP)。聚乙二醇可影响羟磷灰石形态。高温下，柔性更高的聚乙二醇分子形成更大的羟基磷灰石片。低温下，柔性较低的聚乙二醇胶体形成纳米结构的羟磷灰石。
聚乙二醇还可作为泻药使用。
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文献和实验Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates.
Despite possessing only 32 residues, the tsetse thrombin inhibitor (TTI) is among the most potent anticoagulants described, with sub-picomolar inhibitory activity against thrombin. Unexpectedly, TTI isolated from the fly is 2000-fold more active and 180 Da heavier than synthetic and recombinant variants. We predicted the presence of a tyrosine O-sulfate post-translational modification of TTI, prompting us to investigate the effect of the modification on anticoagulant activity. A combination of chemical synthesis and functional assays was used to reveal that sulfation significantly improved the inhibitory activity of TTI against thrombin. Using X-ray crystallography, we show that the N-terminal sulfated segment of TTI binds the basic exosite II of thrombin, establishing interactions similar to those of physiologic substrates, while the C-terminal segment abolishes the catalytic activity of thrombin. This non-canonical mode of inhibition, coupled with its potency and small size, makes TTI an attractive scaffold for the design of novel antithrombotics.
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