(R)-Flurbiprofen

氟比洛芬的COX无活性对映体；体外抑制γ-分泌酶活性；减少Aβ42的形成并改善阿尔茨海默病Tg2576转基因模型中无Aβ斑块的年轻小鼠的轴突运输；抑制RAW 264.7巨噬细胞中的NF-kB活化和DNA结合以及AP-1DNA结合；以1、3和9mg/kg的剂量减轻酵母聚糖诱发的炎症大鼠模型中的爪水肿；体外抑制前列腺肿瘤细胞生长并减少多种小鼠肠道肿瘤模型中的肿瘤生长和转移。A COX-inactive enantiomer of flurbiprofen; inhibits γ-secretase activity in vitro; reduces formation of Aβ42 and improves axonal transport in young Aβ-plaque free mice in the Tg2576 transgenic model of Alzheimer's disease; inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages; reduces paw edema in a rat model of zymosan-induced inflammation at 1, 3, and 9 mg/kg; suppresses prostate tumor cell growth in vitro and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.分子式C15H13FO2分子量244.3OC(=O)[C@@H](C)c1ccc(c2ccccc2)c(F)c1