ALK Inhibitor 2

Generation of Novel Rat and Human Pluripotent Stem Cells by Reprogramming and Chemical Approaches

) have been generated from both mouse and human somatic cells by genetic transduction. We had successfully established novel rat iPSCs (riPSCs), which can be homogenously maintained by LIF and a cocktail of ALK5 inhibitor, GSK3 inhibitor and MEK inhibitor. riPSCs share

【求助】akt的抑制剂有很多种，该怎样选择？

Institute. Perifosine：A p.o.-bioavailable ALK(Alkylphospholipids),inhibits Akt activation。 AT7867 is a potent and oral AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM. GSK690693：selective for the Akt isoforms(inhibits Akt

基因修饰小鼠模型在肿瘤学研究中的应用

，此 PDAC 小鼠有超过 60% 的这些靶基因显示基因敲除，提示 CRISPR/Cas9 介导的突变诱发了肿瘤的形成。同样，利用 Dox 诱导 Cas9 表达的 GEM 模型也被用于验证已知多种肠道肿瘤基因（如 Apc 和 Trp53）。除了修饰 TSGs, CRISPR/Cas9 技术还应用于验证染色体重排的致癌性，如在肺癌病人观察到的 Eml4-Alk 基因的融合现象。另外，应用 GEM 模型对来自临床病人筛选获得的候选潜在癌基因进行验证，也已成为研究肿瘤相关基因功能的常用策略。例如，最近胡卓伟教授