13-OxoODE

13-oxoODE由13-HODE产生，这种脱氢酶存在于大鼠结肠粘膜中，可依赖NAD+。13-OxoODE经直肠滴注到大鼠体内后可刺激细胞增殖。13-OxoODE也已在兔网织红细胞血浆和线粒体膜制剂中检测到，这些膜大多酯化为磷脂。据推测，13-oxoODE的产生与网织红细胞通过15-LO的活性成熟为红细胞有关。13-oxoODE is produced from 13-HODE by a NAD+-dependent dehydrogenase present in rat colonic mucosa. 13-OxoODE stimulates cell proliferation when instilled intrarectally in rats. 13-OxoODE has also been detected in preparations of rabbit reticulocyte plasma and mitochondrial membranes, mostly esterified to phospholipids. Production of 13-oxoODE is putatively linked to the maturation of reticulocytes to erythrocytes through the activity of 15-LO.分子式C18H30O3分子量294.4CCCCCC(=O)/C=C\C=C\CCCCCCCC(=O)O