- ￥2260
- LSM Bio
- 进口
- PAab09304
- 2025年07月16日
- ELISA,WB,IF
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
ubiquitin specific peptidase 10
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
ubiquitin specific peptidase 10
- 抗体英文名：
anti-USP10 antibody,USP10 antibody
- 抗体名：
anti-USP10 抗体,USP10 抗体
- 规格：
100μl
USP10抗体| USP10 antibody
货号 PAab09304
蛋白别名 Deubiquitinating enzyme 10 antibody, KIAA0190 antibody, Ubiquitin thiolesterase 10 antibody, UBPO antibody, USP10
蛋白介绍
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
产品描述
anti-USP10 antibody is a Rabbit Polyclonal antibody againstUSP10..
建议稀释比例
WB : 1:500-1:5000;IP:1:200-1:2000;IF:1:10-1:100
IHC
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab09304(USP10 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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