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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
- 抗体英文名:
anti-RIC8A antibody,RIC8A antibody
- 抗体名:
anti-RIC8A 抗体,RIC8A 抗体
- 规格:
100μg
RIC8A抗体| RIC8A antibody
货号 PAab07294
蛋白别名
蛋白介绍
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
产品描述
anti-RIC8A antibody is a Rabbit Polyclonal antibody againstRIC8A..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human pancreas cancer using PAab07294(RIC8A antibody) at dilution of 1:50
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab07294(RIC8A antibody) at dilution of 1:200(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验了乳腺癌早期阶段的基因组特性,然而有研究表明,癌症从早期过渡到晚期阶段会获得许多基因组改变,而且早期乳腺癌的基因组特征或许并不能代表癌症致死性发生的依据,因此本文研究中,研究人员通过研究分析了 617 份转移性乳腺癌样本中的体细胞改变图谱,研究者指出,当与来自癌症基因组图谱中的早期乳腺癌样本进行对比后,他们发现,9 个驱动基因在表达激素受体但 HER2 水平并不高的转移性乳腺癌中会频繁发生突变,这些驱动基因包括 TP53,ESR1,GATA3,KMT2C,NCOR1,AKT1,NF1,RIC8A
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