RPA2| RPA2 antibody

RPA2抗体| RPA2 antibody

货号   PAab07392

蛋白别名   REPA2 antibody, RPA32 antibody, RPA34

蛋白介绍

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

产品描述

anti-RPA2 antibody is a Rabbit Polyclonal antibody againstRPA2..

建议稀释比例

IHC

Immunohistochemistry of paraffin-embedded human gliomas using PAab07392(RPA2 antibody) at dilution of 1:100

Western blot

A549 cells were subjected to SDS PAGE followed by western blot with PAab07392(RPA2 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">