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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
proteasome (prosome, macropain) activator subunit 4
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IF,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
proteasome (prosome, macropain) activator subunit 4
- 抗体英文名:
anti-PSME4 antibody,PSME4 antibody
- 抗体名:
anti-PSME4 抗体,PSME4 抗体
- 规格:
100μg
PSME4抗体| PSME4 antibody
货号 PAab06897
蛋白别名 KIAA0077
蛋白介绍
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
产品描述
anti-PSME4 antibody is a Rabbit Polyclonal antibody againstPSME4..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验「体温低」竟能更长寿!Nature Aging 研究揭示低温延寿的关键机制
线虫(Caenorhabditis elegans)中,低温(15℃)能促进激活因子 PSME-3 介导的蛋白酶活性,而且 PSME-3 的表达能延长寿命。研究还表明,将体外培养的人类细胞暴露在适度偏低的体温(36℃)下,能激活人类版本的 PSME-3,并有望减少疾病相关的蛋白质改变。 图片来源:Nature Aging 主要研究内容 寒冷诱导的 PA28γ/PSME3 触发蛋白酶体活性 蛋白酶体(一类蛋白质复合物)可以通过降解不需要的、损坏的和错误折叠的易于聚集的蛋白质,包括与疾病相关的突变蛋白,来预防衰老和病理
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