- ￥2860
- LSM Bio
- 进口
- PAab06456
- 2025年07月16日
- ELISA,IP
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
pim-2 oncogene
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
pim-2 oncogene
- 抗体英文名：
anti-PIM2 antibody,PIM2 antibody
- 抗体名：
anti-PIM2 抗体,PIM2 抗体
- 规格：
100μg
PIM2抗体| PIM2 antibody
货号 PAab06456
蛋白别名
蛋白介绍
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
产品描述
anti-PIM2 antibody is a Rabbit Polyclonal antibody againstPIM2..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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