- ￥2262
- LSM Bio
- 进口
- PAab06434
- 2025年07月14日
- ELISA,IHC,WB,IP,IF
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein interacting with PRKCA 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,WB,IP,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein interacting with PRKCA 1
- 抗体英文名：
anti-PICK1 antibody,PICK1 antibody
- 抗体名：
anti-PICK1 抗体,PICK1 抗体
- 规格：
100μg
PICK1抗体| PICK1 antibody
货号 PAab06434
蛋白别名 PRKCABP
蛋白介绍
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
产品描述
anti-PICK1 antibody is a Rabbit Polyclonal antibody againstPICK1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human prostate cancer using PAab06434(PICK1 antibody) at dilution of 1:50
Western blot
mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab06434(PICK1 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验蛋白，使用双杂交系统筛选到的新蛋白已经相当多，并仍在继续扩大，这些蛋白在信号传导方面很可能扮演了重要角色。例如，由于PKC在细胞的发育和分化中所起的中心作用，Staudinger等将PKC的催化部分克隆到GAL4的BD作为“诱饵”来筛选小鼠T细胞的cDNA库，果然找到了一个新的蛋白PICK1，它和PKC的催化结构域专一性地发生交互作用，并用是PKC磷酸化作用的底物，对PICK1进行深入的研究将会使我们再清楚地了解和PKC有关的信号传导途径。4、寻找具有药物治疗作用的小分子多肽用酵母双杂交系统筛选与某种
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