- ￥2262
- LSM Bio
- 进口
- PAab06123
- 2025年07月14日
- ELISA,WB,IHC,IF,FC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
p21 protein (Cdc42/Rac)-activated kinase 4
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,FC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
p21 protein (Cdc42/Rac)-activated kinase 4
- 抗体英文名：
anti-PAK4 antibody,PAK4 antibody
- 抗体名：
anti-PAK4 抗体,PAK4 抗体
- 规格：
100μl
PAK4抗体| PAK4 antibody
货号 PAab06123
蛋白别名 KIAA1142
蛋白介绍
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
产品描述
anti-PAK4 antibody is a Rabbit Polyclonal antibody againstPAK4..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human prostate cancer using PAab06123(PAK4 antibody) at dilution of 1:100
Western blot
COLO 320 cells were subjected to SDS PAGE followed by western blot with PAab06123(PAK4 antibody) at dilution of 1:800(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验第三位的miR-199a/b-3p在肝癌组织中异常的低表达，并且与较差的生存相关。进一步的研究发现，miR-199a/b-3p可通过抑制靶标基因PAK4的表达而抑制PAK4/Raf/MEK/ERK信号通路，并最终抑制肝癌的生长。在SMMC-LTNM人肝癌小鼠模型中，通过注射micrONTM agomir-199a/b-3p，可抑制肿瘤的生长和AFP的表达。 实验方法与结果： 利用SMMC-LTNM人肝癌小鼠模型皮下成瘤两周后，瘤内注射micrONTM
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
sapiens replication protein A2, 32kDa (RPA2), mRNA 537 NM_004356 Homo sapiens CD81 antigen (target of antiproliferative antibody 1) (CD81), mRNA 3638 NM_001743 Homo sapiens calmodulin 2 (phosphorylase kinase, delta) (CALM2), mRNA 4675 NM_004231
所有的看家基因(housekeeping genes)的列表+引物设计服务
)-activated kinase 4 (PAK4), mRNA 375 NM_012407 Homo sapiens protein kinase C, alpha binding protein (PRKCABP), mRNA 553 NM_012111 Homo sapiens chromosome 14 open reading frame 3 (C14orf3), mRNA 717
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