- ￥2262
- LSM Bio
- 进口
- PAab05793
- 2025年07月16日
- ELISA,WB,IHC,IF,FC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
non-POU domain containing, octamer-binding
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,FC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
non-POU domain containing, octamer-binding
- 抗体英文名：
anti-NONO antibody,NONO antibody
- 抗体名：
anti-NONO 抗体,NONO 抗体
- 规格：
100μl
NONO抗体| NONO antibody
货号 PAab05793
蛋白别名 NRB54
蛋白介绍
DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP- dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript.
产品描述
anti-NONO antibody is a Rabbit Polyclonal antibody againstNONO..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab05793(NONO antibody) at dilution of 1:50
Western blot
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab05793(NONO antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验要怎么保存 zjubell 剪下来。TE融解，再就好跟感受态去做转化了。再挑单克隆，再培养多点，再提质粒鉴定。 这样就保种保好了。既有质粒，也有菌液。 zhangyuxianggx 谢谢！pcDNA3-mCherry也用同样的方法溶解下来吗？然后怎么保存？能否详细解释一下pcDNA3-mCherry是什么 nono1986 pcDNA3-mCherry意思是：带有mCherry(红色
【求助】请问 鉴别某种细胞中有某个基因表达 是做PCR 还是做RT-PCR？
有人知道吗？ elainesummer 顶啊！ elainesummer 没人回答吗？ nono1986 RT-PCR! elainesummer 人气好弱啊！ 本文由丁香园论坛提供，想了解更多有用的、有意思的前沿资讯以及酷炫的实验方法的你，都可以成为师兄的好伙伴 师兄微信号：shixiongcoming
soarmlxq 有个同学问我，DNA为什么是双螺旋的？它靠什么来形成双螺旋？我告诉他书上说是碱基堆积力。可是这么回答总觉得不够具体。碱基堆积力究竟是怎样的一种力呢？简单的碱基堆积力就能形成双螺旋结构吗？而且脱氧核苷酸本身也不是平面的，它立体的分子构造是不是也对它形成双螺旋结构有帮助呢？ 另外，如果存在满足以上条件的其他分子双链是否也会形成双螺旋结构？ 请各位高人帮忙给我一个更确切的答案！谢谢！ nono1986
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