Mouse Monoclonal Anti-TIGIT An

gene_symbol：TIGIT
predicted_size：Predicted: 26 kDa.
Uniprot ID：Q495A1
description：Mouse Monoclonal Anti-TIGIT Antibody [7E5]
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer .
immunogen：TIGIT antibody was raised against the extracellular domain of human TIGIT.
recommended_dilution：IHC start at 2 - 5 ug/mL. IF start at 20 ug/mL.
predicted_size：Predicted: 26 kDa.
buffer：TIGIT Antibody is supplied in PBS containing 0.02% sodium azide.
host_species：Mouse
applications：FC, IF, IHC
reactivities：Human