- ￥4875
- 赛默飞（Thermo Fisher）
- PA1884
- 2025年06月25日
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文献和实验-alkyltransferase抑制剂，IC50为5 nM。SGI-1027：SGI-1027是一种DNMT抑制剂，作用于DNMT1， DNMT3A和DNMT3B，IC50分别为6， 8和7.5 μM。Azacitidine：Azacitidine 是胞苷的核苷类似物，通过捕获DNA甲基，特异性抑制DNA methylation(DNA甲基化)。
Inhibition of DNA Methylation in Somatic Cells
the methylation marks through cell division. However, the de novo methyltransferases, Dnmt3a and Dnmt3b, can also contribute to the maintenance of the methylation pattern. Manipulation of these enzymes, especially Dnmt1, provides a means to alter DNA methylation
Relative Quantitation of DNA Methyltransferase mRNA by Real-Time RT-PCR Assay
by at least four DNA methyltransferase (Dnmt) enzymes, including Dnmt1, Dnmt2, Dnmt3a, and Dnmt3b. To understand fully how DNA methylation is involved in gene regulation, knowledge of Dnmt mRNA transcript levels is required, both as a surrogate measure of Dnmt protein
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