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文献和实验RNAi Knockdown of Redox Signaling Protein Ape1 in the Differentiation of Mouse Embryonic Stem Cells
in early developmental events, gene knockout approaches have been traditionally used; however, this is a time-consuming and expensive approach. Recently, we have shown that siRNA is an effective strategy to knockdown target gene expression, such as Ape1
. The activation of NM23-H1 occurs indirectly, through the cleavage of proteins that inhibit NM23-H1 in the SET complex, which includes SET, Ape1, pp32 and HMG2. SET is a substrate for the Granzyme A protease, and SET cleavage relieves NM23-H1 inhibition to cause
【原创】自己总结的RNAi干预的癌基因(75条) 大家一起来补全好吗
自己总结的RNAi干预的癌基因 75条(有部分重复) 大家一起来补全吧 最近在考虑做哪个基因 所以顺便总结了一下 大家多提意见 AML1/MTG8 (205) APE1 #3 ATF2 #3 Bax (202) bcl-2 Antiapoptotic Esophageal adenocarcinoma BCL-2,xIAP(138, 213) BCR-AbL (136, 137) B-raf Serine/threonine kinase Malignant
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