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文献和实验The Reconstitution of Actin Polymerization on Liposomes
-associated actin as well as the regulation and mechanics of actin assembly. Branched actin polymerization on membranes is catalyzed by the Arp2/3 complex. Signaling events leading to the activation of the guanosine triphosphate (GTP)-binding protein Cdc
-dependent mechanisms important for membrane ruffling, endocytosis and cell motility. Cortactin binds to and regulates the Arp2/3 complex, a multi-protein complex that regulates filopodia and lamellipodia formation by promoting “branched actin polymerization
Functional Characterization of Proteins Regulating Actin Assembly
by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin‐based motility. J. Cell Biol. 146:1319‐1332. Hug, C., Jay, P.Y., Reddy, I., McNally
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