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文献和实验Polymorphisms of DNA Repair Genes: ADPRT, XRCC1, and XPD and Cancer Risk in Genetic Epidemiology
Many studies have suggested that adenosine diphosphate ribosyl transferase (ADPRT), X-ray repair cross-complementing 1 (XRCC1), and xeroderma pigmentosum complementary group D (XPD) are three major DNA base excision repair (BER) genes
Cytogenetic Challenge Assays for Assessment of DNA Repair Capacities
aberrations as a biomarker to indicate DNA repair proficiency. The assay was used successfully to demonstrate base- and nucleotide-excision repair deficiency in certain polymorphic DNA repair genes, namely XRCC1 751Gln and XPD 312Asn, respectively. In addition
to its partner protein hHR23B, is also involved in damage recognition. TFIIH, a transcription initiation complex, which includes the XPB and XPD helicases as subunits (2 ), is involved in local opening of DNA around the site of damage (3 ). The incisions
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