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文献和实验,而p38δ主要存在于腺体组织。 研究证实,p38MAPK通路的激活剂与JNK通路相似。一些能够激活JNK的促炎因子(TNFα、IL-1)、应激刺激(UV、H2O2、热休克、高渗与蛋白合成抑制剂)也可激活p38,此外,p38还可被脂多糖及G+细菌细胞壁成分所激活。p38信号通路也由三级激酶链组成,其上游激活物为MKK3、MKK4及MKK6,与MKK4不同,MKK3、MKK6仅特异性激活p38。体外细胞转染 实验表明,MEKK2。MEKK3可通过激活MKK4同时激活JNK和p38,而MEKK3
Investigating the Cellular BMK1/ERK5 Signaling Pathway
the kinases MEKK3, MEK5, and BMK1 (4 ,5 ,8 –10 ). We have shown that the activation of this signal transduction pathway is required for growth factor-mediated cell proliferation and cell-cycle progression (5 ,11 ).
Activity Assays for Extracellular Signal-Regulated Kinase 5
in mammalian cells and is part of a three kinase cascade involving a MAPK kinase (MEK5) and MAPK kinase kinase (primarily MEKK2 and MEKK3). ERK5 is important for proliferative responses to growth factors like epidermal growth factor and stress responses
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