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文献和实验In Vitro Characterization of Intestinal and Hepatic Transporters: MRP2
. Multidrug resistance-associated protein 2 (MRP2, ABCC2 ) is an ATP-dependent efflux pump that belongs to the ATP binding cassette (ABC) superfamily of transporters, and is localized at the apical membrane of polarized cells from a variety of human tissues
transporters, such as ABCB1 (P-glycoprotein/MDR1), ABCC1 (MRP1/GS-X pump), and ABCC2 (MRP2/cMOAT). To gain insight into the relationship between the molecular structure of compounds and the ABCG2-mediated transport activity, we have developed a high-speed
Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics
-dependent efflux, their tissue expression and cellular localization vary. MRP2 is most highly expressed in the liver at the canalicular domain and is the primary focus of this chapter. Several in vitro approaches to study drug transport in the liver
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