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文献和实验LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium
, midazolam, nordiazepam, oxazepam, temazepam, clonazepam and 7-aminoclonazepam in urine, serum, plasma, and meconium. The urine and meconium specimens undergo enzyme hydrolysis to convert the compounds of interest to their free form. All specimens
(UPLC) coupled with tandem mass spectrometry (MS/MS). Analytes included alprazolam, temazepam, oxazepam, nordiazepam, clonazepam, lorazepam, diazepam, chlordiazepoxide, midazolam, flunitrazepam, 7-aminoclonazepam, and 7-aminoflunitrazepam. Sample
0.6~1.8g/日,分3次服。 氯硝西泮(clonazepam,氯硝安定)起始儿童0.01~0.03mg/kg/日;成人不超过1.5mg/日,分3次服。以后儿童每3天加 0.25~0.5mg /日;成人加0.5~1mg/日。最大耐受量儿童0.2mg/kg/日;成人20mg/日。 硝西泮(nitrazepam,硝基安定)用于婴儿痉挛和不典型小发作,0.5~1.0mg/kg/日。 地西泮(diazepam,安定)用于癫痫持续状态,5~10mg静脉注射,间隔
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