- ￥5139
- 赛默飞（Thermo Fisher）
- MA513854
- 2025年07月13日
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文献和实验Generating Inhibitors of P-Glycoprotein: Where to, Now
The prominent role for the drug efflux pump ABCB1 (P-glycoprotein) in mediating resistance to chemotherapy was first suggested in 1976 and sparked an incredible drive to restore the efficacy of anticancer drugs. Achieving this goal
Measurement of P-glycoprotein Function
The MDR 1-encoded P-glycoprotein (Pgp), when overexpressed in tumor cells, confers resistance to many clinically important classes of anticancer drugs. This phenomenon is called multidrug resistance (MDR). The finding that this gene
Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation
Modulation of P-glycoprotein (Pgp)-mediated transport has significant pharmacokinetic implications for Pgp substrates. Pharmacokinetic alterations may be at the systemic (blood concentrations), regional (organ or tissue concentrations
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