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文献和实验Sci Adv:蒋若天 / 温祥毅揭示钾离子通道参与健康和衰老视网膜视觉信号调控新机制
视网膜神经节细胞(Retinal ganglion cell, RGC)不仅接收上级神经元的信号,还在信号进入大脑前,通过神经环路及离子通道等对视觉信息进行线性或非线性计算。尽管多种机制可以调节 RGC 的兴奋性及动作电位放电模式,但 RGC 兴奋性变化如何调控初级视觉环路,特别是如何对非线性视觉信号处理的分子机制和原理尚不完全清晰。 在光感受器细胞和双极细胞以及双极细胞和 RGC 的突触之间,神经元活动介导的胞外酸化(extracellular acidification)可将突触
Computational Modeling of Signaling Networks for Eukaryotic Chemosensing
The task of developing and simulating computational models of signaling networks for eukaryotic chemosensing confronts the modeler with several challenges: (1) The stimuli that initiate the cellular responses one wishes to study are provided
Methods to Assess Changes in the Pattern of Nuclear Phosphoinositides
sub-cellular pools has led to the challenging task of understanding how the different pools are regulated and how changes in the mass of lipids within the nucleus can modulate nuclear specific pathways. Here we describe methods to determine
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