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文献和实验Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface-associated heparan sulfate proteoglycans (HSPGs). In this chapter, we provide protocols for studying HSPG-mediated uptake of polyamines in various cell
Studies of Proteoglycan Involvement in CPP-Mediated Delivery
Cell-penetrating peptides (CPPs) are widely used to deliver macromolecular cargoes to intracellular sites of action. Many CPPs have been demonstrated to rely on cell surface heparan sulfate proteoglycans (HSPGs) for efficient cellular entry
Serglycin: The Master of the Mast Cell
Serglycin is a proteoglycan composed of a relatively small (∼17 kDa) core protein to which sulfated glycosaminoglycans of either heparin, heparan sulfate or chondroitin sulfate types are attached. Serglycin is expressed in many cell types
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