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文献和实验The Regulation of Tumor Suppressor Genes by Oncogenes
Tumor suppressor genes (TSGs) and oncogenes represent the ying and the yang of cell growth, differentiation, and survival control. TSGs such as p53, the retinoblastoma (RB) gene product, and the cyclin kinase inhibitor (CKI) proteins p21 Cip
Sequencing of the Tumor Suppressor Gene TP 53
The tumour suppressor gene, TP 53 (commonly also called p53 ) has multiple, important cellular functions involving control of apoptosis, downstream cell cycle regulation via p21 and cyclin dependent kinases, and control of tumour angiogenesis
Microarray Approaches for Analysis of Tumor Suppressor Gene Function
Many tumor suppressor genes are known to function at least in part through regulation of the transcription of downstream effector genes (Table 1 ). A major example of such a transcriptional regulator is p53, one of the most commonly mutated
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