FITC anti-human CD340 (erbB2/H

FITC anti-human CD340 (erbB2/HER-2) Antibody
24D2
Catalog# / Size 324404 / 100 tests
Clone
Regulatory Status RUO
Other Names HER2/erbB2, tyrosine kinase cell surface receptor HER2, oncogene ERBB2, oncogene NGL,
neuroblastoma- or glioblastoma-derived, HER-2
Isotype Mouse IgG1, κ
Description CD340 is also known as HER2/erbB2, tyrosine kinase cell surface receptor HER2, oncogene
ERBB2, and oncogene NGL, neuroblastoma- or glioblastoma-derived. It is a member of the
epidermal growth factor receptor family of cell membrane tyrosine kinases containing a single
transmembrane domain and has an approximate molecular weight of 185 kD. CD340 contains
three furin repeats and two cheY homologous receiver domains in the extracellular region
(ECR). The HER2/erbB2 protein is expressed on many tumor cells, including some breast
cancers, lung adenocarcinoma, gastric cancer, ovarian cancer, gliblastoma, some c-ALL blasts
and bone marrow mesenchymal stem cells. Although the erbB2/HER2 protein contains no
ligand binding domain, this protein interacts with other EGF receptor family members to form a
heterodimer, stabilize ligand binding, and enhance kinase-mediated downstream signaling.
CD340 has been shown to be involved in embryonic development and cancer progression;
this protein is amplified in adenocarcinoma of the lung, some breast cancers, glioblastoma,
gastric cancer, and ovarian carcinoma, where it functions as an oncogene. Overexpression of
erbB2 in breast cancers has been shown to confer Taxol resistance and is a therapeutic target
in a number of human cancers. The erbB2/HER-2 protein has been shown to interact with a
large number of proteins, including SHC1, EGF receptorm, neuroregulin 1, c-Src, integrin β4,
Grb2, Grb7, SOS1, caveolin 1, JAK2, PAK1, FAK, and β-catenin, among others. CD340 is
extensively modified by tyrosine phosphorylation on multiple residues (Y1023, Y1139, Y1196,
Y1221, Y1222, Y1248).
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen NIH-3T3 transfected with human HER-2
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography, and conjugated with FITC under optimal
conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.