- ￥10189
- BioLegend-HK
- 935004
- 美国
- 2025年07月14日
- 免疫荧光，流式
- 小鼠
- 人
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- 抗体名：
Ultra-LEAF™ Purified anti-human Neurturin
- 抗体英文名：
Ultra-LEAF™ Purified anti-human Neurturin
- 应用范围：
免疫荧光，流式
- 宿主：
小鼠
- 供应商：
上海善然生物
- 库存：
4-5周
- 抗原来源：
小鼠
- 保质期：
2-3年左右
- 适应物种：
人
- 标记物：
Ultra-LEAF™ Purified
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
1mg
Ultra-LEAF™ Purified anti-human Neurturin Antibody
A16100E
Catalog# / Size 935003 / 100 µg
935004 / 1 mg
Clone
Regulatory Status RUO
Other Names NRTN, NTN
Isotype Mouse IgG2b, κ
Description Neurturin belongs to the GDNF family of ligands, which consists of 4 members: GDNF,
Neurturin, Artemin, and Persephin. GDNF family members orchestrate multiple aspects of the
development and maintenance of the central and peripheral nervous systems. These GDNF
family ligands signal through a multicomponent receptor system composed of a common
signaling component RET (receptor tyrosine kinase) and one of the high affinity binding
coreceptors GFRα (α1-α4). Neurturin is a GDNF family member that functions as a ligand for
the GFRα2 and RET complex. Neurturin is a potent neurotrophic factor that can promote the
survival of numerous neuronal populations, which include the sympathetic, nodose, and dorsal
root ganglion sensory neurons. Neurturin is synthesized as a precursor protein that is cleaved
to release the carboxy-terminal domain. The carboxy-terminal domain contains seven
conserved cysteine residues that are necessary for the formation of the cysteine-knot and the
single interchain disulfide bond. The functional form of human Neurturin is a disulfide-linked
homodimer of the carboxy-terminal 102 amino acid residues. Studies have shown positive
results for Neurturin in protecting and repairing dopaminergic neurons in various models of
Parkinson's disease. In association with mutations of the RET gene, genetic variations in
Neurturin may contribute to Hirschsprung's disease.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Recombinant human Neurturin
Formulation 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
Endotoxin Level Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
Preparation The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3
mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and
expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™
solution contains no preservative; handle under aseptic condition
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